Unity™ Non-Invasive Prenatal Test (NIPT)
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Unity™ Non-Invasive Prenatal Test (NIPT)
Unity™ aneuploidy NIPT works by analyzing the cell-free DNA in maternal blood. With advanced genetic technology, Unity™ aneuploidy can analyze DNA from the placenta for certain chromosome conditions that can affect a baby’s health as follow.
- Trisomy 21 Down’s syndrome
- Trisomy 18 Edward’s syndrome
- Trisomy 13 Patau’s syndrome
- Sex chromosome
- Fetal RhD
Unity™ aneuploidy screens for genetic abnormalities following the ACOG guideline as detailed below.
Conditions screened | Sensitivity | Specificity | Positive predictive value | Negative predictive value | |
(average risk population) | (high risk population) | ||||
Trisomy 21 | 99.50% | > 99.9% | 96% | 99% | > 99.9% |
Trisomy 18 | 99.90% | > 99.8% | 52% | 90% | > 99.9% |
Trisomy 13 | 99.60% | > 99.9% | 58% | 92% | > 99.9% |
Monosomy x | 95.40% | > 99.7% | 64% | 64% | > 99.9% |
Sex chromosome aneuploidy (xxx / xxy / xyy) | Reported When identified | > 99.9% | N/A | N/A | > 99.9% |
Presence of y chromosome | > 99.9% | > 99.9% | N/A | N/A | > 99.9% |
Rhd** | 100% (99–100%) | 100% (98–100%) | N/A | N/A | N/A |
* Performance metrics are estimated by combining the data from 7,864 clinical samples from pregnant patients and the fetal fraction distribution characteristics obtained from 11,610 clinically ordered samples. The PPV and NPV were calculated based on the sensitivity, specificity, and expected prevalence at 9-14 weeks of gestation for average risk (30 year old) and high risk (40 year old) pregnant patients.
**Alford, B., Landry, B. P., Hou, S., Bower, X., Bueno, A. M., Chen, D., … & Gray, K. J. (2023). Validation of a Non-invasive Prenatal Test for Fetal RhD, C, c, E, Kell and FyA Antigens. medRxiv, 2023-03.
Who should get tested?
- All expectant mothers starting from the 10th week of pregnancy onward.
- Pregnant individuals aged 35 and above.
- Pregnant women under 35 who have not undergone any previous screening.
- Pregnant individuals identified as at higher risk for abnormalities through serum screening tests.
- Certain abnormalities detected through ultrasound examinations.
- Couples with a history of children with chromosomal abnormalities.
- Couples with a history of infertility.
Key highlight
- Screening for Chromosomal aneuploidy such as Trisomy 21 with the high accuracy (99%)
- Only 10 weeks of G.A. are available
- No risk for the baby only 20 mL of maternal blood
- Knowing the gender of your baby (optional) with beyond 99% of accuracy
- Only Unity™ aneuploidy can Identifies fetal D antigen (RhD)
- In case of false – negative the company will be compensated pay in amount of 300,000 THB
- Every high-risk case will got the supporting pay for diagnostic test (not excess 15,000 THB)
Sample Collection
- Collect a 20 mL blood sample from the pregnant mother starting at 10 weeks of pregnancy.
- Got the result within 18-22 Days.(powered by laboratory in USA)
